<p>Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib</p>
نویسندگان
چکیده
منابع مشابه
Signaling pathways involved in chronic myeloid leukemia pathogenesis: the importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells
Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to important signaling pathways such as Hedgehog and Notch that are essential ...
متن کاملGATA2 Inhibition Sensitizes Acute Myeloid Leukemia Cells to Chemotherapy
Drug resistance constitutes one of the main obstacles for clinical recovery of acute myeloid leukemia (AML) patients. Therefore, the treatment of AML requires new strategies, such as adding a third drug. To address whether GATA2 could act as a regulator of chemotherapy resistance in human leukemia cells, we observed KG1a cells and clinical patients' AML cells with a classic drug (Cerubidine) an...
متن کاملCorrection: GATA2 Inhibition Sensitizes Acute Myeloid Leukemia Cells to Chemotherapy
[This corrects the article DOI: 10.1371/journal.pone.0170630.].
متن کاملInhibition of Euchromatic Histone Methyltransferase 1 and 2 Sensitizes Chronic Myeloid Leukemia Cells to Interferon Treatment
BACKGROUND H3K9 methylation is one of the essential histone post-translational modifications for heterochromatin formation and transcriptional repression. Recently, several studies have demonstrated that H3K9 methylation negatively regulates the type I interferon response. RESULTS We report the application of EHMT1 and EHMT2 specific chemical inhibitors to sensitize CML cell lines to interfer...
متن کاملCorrection: Aclacinomycin A Sensitizes K562 Chronic Myeloid Leukemia Cells to Imatinib through p38MAPK-Mediated Erythroid Differentiation
[This corrects the article DOI: 10.1371/journal.pone.0061939.].
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ژورنال
عنوان ژورنال: Cancer Management and Research
سال: 2020
ISSN: 1179-1322
DOI: 10.2147/cmar.s253367